Pilot study finds “smart drug” Aderall has limited benefits for healthy students, and may harm working memory

GettyImages-1009056818.jpgBy Emma Young

Stimulants available on prescription such as Adderall improve cognitive functioning as well as attention in people with ADHD, but many students without this condition also take them, believing that they will act as “smart drugs” and boost their cognition, and so their academic performance. The limited research to date into whether this is actually the case has produced mixed results. A new double-blind pilot study of healthy US college students, published in Pharmacy, found that though Adderall led to minor improvements in attention, it actually impaired working memory. 

The researchers, from the US and Iceland, recruited 13 healthy college students who were given a 30 mg dose of Adderall in capsule form before one test session, and a placebo capsule before another (adults with ADHD who have been prescribed Adderall take anywhere between 5 and 60 mg per day). The sessions lasted five and a half hours. During this time, the participants completed six neurocognitive tasks (timed to occur when the drug’s effect would be at its peak – between 90 and 210 minutes after taking the capsule). Every half hour, the students also reported how much they were feeling any drug effects and their emotional state, and their heart rate and blood pressure were measured. 

The neurocognitive measures assessed working memory, memory for increasingly complex stories, attention and vigilance, memory of past cognition and ability to self-regulate, and also reading. The students also indicated whether they thought the drug had positively or negatively affected their performance on the tests. 

The results showed that the drug boosted levels of positive emotion and raised heart rate and blood pressure. It also led to slight improvements on the tests of attention and focus. But it worsened performance on one of the measures of working memory (recall of a string of digits), and also participants’ perceptions of their past cognitive and self-regulation functioning. It had no effect on reading performance. 

“While improving attention skills, [Adderall] may simultaneously degrade students’ confidence in their abilities to problem solve, complete tasks and interact with others,” the researchers write.

For the large numbers of students who report taking stimulants, these results suggest that while the drugs might have a slight impact on attention, they probably won’t do much to enhance their academic performance (while Adderall can address a neurocognitive deficit – in people with ADHD – it does not seem to lead to the same improvements in already healthy people). And, besides the hit to working memory, there are other recognised downsides to taking such drugs: common side effects of Adderall include headaches, digestive problems and insomnia. But this was a pilot study, and the sample size was certainly small. More work in the area is clearly needed.  

Neurocognitive, Autonomic, and Mood Effects of Adderall: A Pilot Study of Healthy College Students

Emma Young (@EmmaELYoung) is Staff Writer at BPS Research Digest

11 thoughts on “Pilot study finds “smart drug” Aderall has limited benefits for healthy students, and may harm working memory”

  1. I think this issue applies to ALL psychiatric drugs – not just this particular drug. Also, there are many biases that happen when these drugs are tested by profit-driven big pharma – check out the articles below:

    Lancee, M., et al. (2017). Outcome reporting bias in randomized-controlled trials investigating antipsychotic drugs. Translational Psychiatry, 7, e1232.

    Zubenko, G. S., Sommer, B. R., & Cohen, B. M. (2018). On the Marketing and Use of Pharmacogenetic Tests for Psychiatric Treatment. JAMA psychiatry.

    Roest, A. M., et al. (2015). Reporting bias in clinical trials investigating the efficacy of second-generation antidepressants in the treatment of anxiety disorders: a report of 2 meta-analyses. JAMA Psychiatry, 72(5), 500-510.

    Turner, E. H., et al. (2008). Selective publication of antidepressant trials and its influence on apparent efficacy. New England Journal of Medicine, 358(3), 252-260.

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  2. This Pilot study is incredibly poor if it seems to suggest that Adderall harms performance.

    The recommended dose of Adderall for Adults with ADHD is to take 5mg/day, and then increase it by 5mg a week until symptoms are manageable. Rarely should people be exceeding 40mg/day.

    Even college students who illegally abuse the drug do not take more than 5-10mg in order to achieve their desired performance.

    The study administers a 30mg dose to people who have no resistance or experience with the drug. Anyone experienced in psychiatric drugs knows that taking a high dose without easing into the dose is an overwhelming experience and would harm performance. Imagine consuming 2 Pints of Coffee before work! You’d be useless – no one does that except those with the highest level of caffeine resistance!

    The author.Emma Young, is a poor journalist who should be ashamed of herself for writing such a misleading article without understanding the nature of how students abuse stimulants and how that relates to the study.

    Liked by 1 person

    1. Out of curiosity, I checked the published article, and it says that the 30 mg oral dose has a well-documented safety profile in young adults (they provide a reference as well).
      Also, if the pilot study were so poorly conducted, it wouldn’t have got published in a peer-reviewed academic journal.

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